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PubMed , American Journal of Epidemiology , vol

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Taken together, these methodological constraints mean that the robust and consistent epidemiological associations reported in this literature should be regarded as hypothesis-generating signals rather than definitive evidence of a causal neuroprotective effect

Excess weight promotes the development of a wide range of pathologies (insulin resistance, hypertension, chronic inflammation, dyslipidemia), which increase the risk of complications such as type 2 diabetes, cardiovascular disease, hepatic steatosis, several types of cancer and reduce life expectancy

In a cardiovascular outcomes trial of liraglutide 1.8 mg, weight loss was sustained over a median trial period of 3.5 years in patients with type 2 diabetes who had either cardiovascular disease or risk factors for cardiovascular disease [60]